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PostSubject: An drug Wed Apr 20, 2011 8:04 pm

Methadone hydrochloride (referred to l-Methadone) for the μ opioid receptor agonists. It is similar to the efficacy of morphine has analgesic effect and can cause respiratory depression, miosis, sedation and so on. Compared with morphine, with a role in a long time, not easy to produce tolerance, drug dependence and low, is synthesized in Germany during World War II instead of the narcotic analgesics morphine. 60 in the early 20th century, found the drug in treating heroin dependence and the role of alternative maintenance treatment efficacy. Good oral absorption of methadone, 30 minutes after the onset of medication, 4 hours peak plasma concentration, the duration of action of 24 to 36 hours, t1 / 2 was 15 to 18 hours, plasma protein binding rate of 85% to 90%; mainly in liver and excreted by the kidneys and bile, repeated administration of the role of organized accumulation. ] l-Methadone
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PostSubject: Re: An drug Tue May 03, 2011 8:47 pm

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